slama, K., Salah El din, A., Elgohary, A., Mostafa, B. (2020). Evaluation of Vaginal Fluid Urea and Creatinine as Biomarkers of Preterm Premature Rupture of Membranes. Benha Medical Journal, 37(special issue (Surgery)), 106-118. doi: 10.21608/bmfj.2020.126032
Khaled slama; Ahmed Salah El din; Aymen Elgohary; Basma Mostafa. "Evaluation of Vaginal Fluid Urea and Creatinine as Biomarkers of Preterm Premature Rupture of Membranes". Benha Medical Journal, 37, special issue (Surgery), 2020, 106-118. doi: 10.21608/bmfj.2020.126032
slama, K., Salah El din, A., Elgohary, A., Mostafa, B. (2020). 'Evaluation of Vaginal Fluid Urea and Creatinine as Biomarkers of Preterm Premature Rupture of Membranes', Benha Medical Journal, 37(special issue (Surgery)), pp. 106-118. doi: 10.21608/bmfj.2020.126032
slama, K., Salah El din, A., Elgohary, A., Mostafa, B. Evaluation of Vaginal Fluid Urea and Creatinine as Biomarkers of Preterm Premature Rupture of Membranes. Benha Medical Journal, 2020; 37(special issue (Surgery)): 106-118. doi: 10.21608/bmfj.2020.126032
Evaluation of Vaginal Fluid Urea and Creatinine as Biomarkers of Preterm Premature Rupture of Membranes
Department of Obstetrics and Gynecology, Faculty of Medicine, Benha University, Egypt.
Abstract
Background: PROMs occurs in 10% of all term pregnancies and about 2- 4% of preterm pregnancies and is associated with complications such as infection and preterm birth. Vaginal fluid urea and creatinine levels may be helpful in the diagnosis of PROM. Objectives: To evaluate the reliability of vaginal washing fluid urea and creatinine as biomarkers for diagnosis of preterm PROM. Subjects and Methods:A prospective case control study was conducted at the Obstetrics and Gynecology Department; Benha University Hospital during the period from September 2018 to September 2019. The study included 100 cases: 50 inpatient cases with preterm PROM and 50 cases from those attending outpatient clinics for routine antenatal care. All patients underwent speculum examination, nitrazine paper test, and U/S. Results: The creatinine levels were 0.35 ±0.12 mg/dl and 0.16± 0.08 mg/dl in confirmed cases and controls, respectively. The urea levels were 6.5 ±2.48 mg/dl and 3.4 ±1.68 mg/dl in confirmed cases and controls, respectively. There was a highly significant difference regarding creatinine level and urea level (P < 0.001). Sensitivity, specificity, PPV and NPV for creatinine level were 100%, 84%, 86,2% and 100%, respectively. Sensitivity, specificity, PPV and NPV, for urea level was 100%, 80%, 83.3% and 100%, respectively, with a cut‑off value of 0.2 mg/dl for creatinine level and 3 mg/dl for urea level. Conclusions: Detection of vaginal fluid urea and creatinine to diagnose PROM is a simple, reliable and rapid test with high sensitivity, specificity, PPV, NPV.
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