Document Type : Original Article
Authors
1
Assistant Professor of Pediatrics Department, Faculty of Medicine, Benha University, Benha, Egypt.
2
Professor of Pediatrics, Faculty of Medicine, Benha University
3
Faculty of Medicine, Department of Pediatrics and Neonatology, Benha University
4
department of clinical and chemical pathology faculty of medicine benha university
5
Specialist of National Heart Institute, Giza, Egypt.
6
Lecturer of Pediatric Faculty of Medicine – Benha University
Abstract
Background: Cardiomyocyte oedema and cardiac hypertrophy are among the significant health consequences of chronic liver diseases (CLD) in adolescents, which are experiencing rapid growth. Purpose: To evaluate soluble urokinase receptor (SuPAR) as a valuable marker for clinical cardiac dysfunction in children with CLD. Methods: This case-control study included two groups: CLD group: involved 48 children with CLD of different etiologies; and control group; involved 48 healthy children, matched for age and sex of studied group. All the participants were subjected to full history taking, clinical examination and laboratory investigations and liver biopsy, echocardiography and assessment of SuPAR by ELISA. Results: CLD group had statistically significant higher LVIDD, IVSD, LVPWD, LVMI, DT of mitral valve, E of tricuspid valve and statistically lower TAPSE compared to control group. CLD group had statistically significant higher suPAR compared to control group (91.9±31.3 vs 59.0±19.5 pg/ml), p<0.001.suPAR had a significant positive correlation with (ALT, AST, GGT, INR, total and direct bilirubin, liver span, spleen size, degree if fibrosis, HAI score, Aspartate aminotransferase to platelet ratio index (APRI) score and FIB-4) and statistically negative correlation with (hemoglobin and platelets). suPAR had a significant positive correlation with (LVIDD, IVSD, ICT of left ventricle), and had a significant negative correlation with (TAPSE, S of left ventricle, S, E of right ventricle). Conclusion: Children with CLD had significantly higher suPAR compared to healthy children. suPAR levels correlates positively with markers of liver disease severity and with echocardiographic changes.
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