Association between Serum Uric Acid and Lactate Levels in Patients with Obstructive Sleep Apnea and Their Relation with Disease Severity

Elnaggar, Marwa E.; Mohammed, Ahmed A.; Abd El-Ghafar, Amira O.; Ali, Mai A.; Mohammed, Etemad A.

doi:10.21608/bmfj.2025.402281.2528

Association between Serum Uric Acid and Lactate Levels in Patients with Obstructive Sleep Apnea and Their Relation with Disease Severity

Articles in Press

Document Type : Original Article

Authors

¹ Assistant Professor of Chest Diseases, Faculty of Medicine, Benha University

² Professor of Chest Diseases, Faculty of Medicine, Benha University

³ Lecturer of clinical and chemical pathology, Faculty of Medicine, Benha University

⁴ M.B.B.Ch, Faculty of Medicine, Benha University

10.21608/bmfj.2025.402281.2528

Abstract

Background: Obstructive sleep apnea (OSA) is the most prevalent variation of sleep-disordered respiration. Recurrent compression of the upper airway during sleep, which results in oxygen desaturation and subsequent arousals from sleep, is the hallmark of OSA. This study aimed to determine the existence of a correlation between OSA and serum uric acid and lactate levels as potential indicators of tissue hypoxia, as well as their correlation with disease severity. Methods: This prospective cross-sectional study included 50 patients with sleep related breathing disorders who were attend at sleep study unit, Chest department at Benha University Hospital. Results: There was a significant positive correlation between serum uric level after sleep and apnea–hypopnea index (AHI) and OSA classification, lactate after sleep, Epworth sleepiness scale (ESS),and oxygen desaturation index. There was a significant negative correlation between serum uric level after sleep and mean SpO2, lowest SpO2 and total sleep time. There was a significant positive correlation between lactate level after sleep and AHI and OSA classification, ESS and oxygen desaturation index. There was a significant negative correlation between lactate level after sleep and mean SpO2, lowest SpO2 and total sleep time. The serum uric acid and lactate after sleep was significantly higher compared to before sleep (P <0.001). Conclusion: There was a significant association between sleep-related breathing disorders, particularly OSA and increased levels of serum uric acid and lactate, suggesting tissue hypoxia as a potential mechanism in OSA severity.

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