Benha University, Faculty of Medicine
Benha Medical Journal
1110-208X
36
3
2020
03
01
Pharmacogenomics and Heart Failure Patients on Carvedilol
77
88
75818
10.21608/bmfj.2020.75818
EN
Aya Mohamed
Bahgat Awad
Pharmacology department, faculty of medicine, zagazig university
Journal Article
2020
03
05
Pharmacogenomics is a science of how genes affect person’s response to drugs. This field integrates pharmacology and genomics for development of safe and effective medications which tailored to person’s genetic makeup. Genes are instructions, written in deoxyribonucleic acid (DNA), for constructing protein molecules. Diverse people can have various versions of the same gene.Cardiovascular diseases remain number one killer of mankind, and heart failure (HF) pays a fair contribution to this spectrum of diseases.Many options are available for the drug treatment in HF patients, with recent trends depending mainly on beta blockers (BBs) and angiotensin-converting-enzyme inhibitor (ACEIs) in addition to diuretics.BBs exert their effects by antagonizing the activation of β-ARs, and α-ARs in case of carvedilol. Variations of these receptors can be involved in how HF patients with various genotypes respond to BBs. Therefore, we discuss some of the most commonly described single nucleotide polymorphisms (SNPs) in this review of literatures.
https://bmfj.journals.ekb.eg/article_75818_4bc0a5987ba216c41960dfe9d92022bd.pdf
Benha University, Faculty of Medicine
Benha Medical Journal
1110-208X
36
3
2020
03
01
Female’s Infertility Rules of Ultrasound And Colour Duplex in Assessment of Pelvic Causes
89
97
75828
10.21608/bmfj.2020.75828
EN
Maher
Ali
aDepartment obstetric and gynecology, faculty of medicine Benha University, Egypt
Ahmed
Yousef
department of Radiodiagnosis and Medical Imaging, faculty of medicine Benha University, Egypt
Hamada
Khater
department of Radiodiagnosis and Medical Imaging, faculty of medicine Benha University, Egypt
Journal Article
2020
03
05
<strong>Background: </strong>The causes of infertility are variable. This study critically evaluates the utility of ultrasound in the diagnosis of the female pelvic pathology. The diagnosis should be more accurate, cost effective, expeditious, reliable and as minimally invasive as possible.<br /> <strong>Methods:</strong> The data were collected from about 750 infertile women were investigated and chosen sample was 255 cases. All patients underwent two ultrasound examinations in the follicular phase (day 13 of the cycle). Endovaginal ultrasound was done in only 80 of our cases about 60 patients of them were normal and 20 of them were abnormal .13 of them had ovarian causes and 7 had uterine causes. Endovaginal was superior to trans abdominal U/S<br /> <strong>Results:</strong> 119 cases represented U/S abnormalities and the rest were normal according to ultrasound. PCO demonstrated with (73.95%) of the. other factors represented in only (26.5%), which was subdivided into; uterine fibroid (10.92%), bicornuate and ovarian cystic (2.52%), endometriosis, thin endometrium and septate uterus are same percentage (1.68%), congenital small uterus and ovaries (4.20% ) , and PID (0.84%),<br /> <strong>Conclusion:</strong> Ultrasound is one of the non-invasive processes that provides similarly better anatomical and even better physiological data than traditional surgical procedures. The role of ultrasonographic technology, especially trans vaginal, SHG, Doppler and 3D ultrasonography, can improve the female pelvic assessment. Ultrasonographic procedures should be combined as an essential examination in the basic infertility examination.
https://bmfj.journals.ekb.eg/article_75828_ad9da0b2475eb33f1cb9047978a100e5.pdf
Benha University, Faculty of Medicine
Benha Medical Journal
1110-208X
36
3
2020
03
01
calcaneal lengthening for correction of symptomatic flexible flat foot in children.
98
106
75839
10.21608/bmfj.2020.75839
EN
Elshafey Abdel Fattah
Elshafey
orthopedic department, 6th october health insurance hospital, dokki, giza
Mohamed
Hegazy
department of orthopedic, Faculty of Medicine, Benha University, Egypt
Hani
Bassiouni
department of orthopedic, Faculty of Medicine, Benha University, Egypt
Mohamed
Al-Ashhab
department of orthopedic, Faculty of Medicine, Benha University, Egypt
Journal Article
2020
03
05
<strong>Background;</strong> The purpose of this study was to evaluate the clinical, functional and radiological outcome of calcaneal lengthening osteotomy for the treatment of symptomatic flatfoot deformity in children.<br /> <strong>Methods; </strong>A prospective multicentre study on 29 feet of 23 patients who underwent lateral calcaneal lengthening for symptomatic flatfoot in children in the period between October 2015 and June 2017. Inclusion criteria were symptomatic flexible flatfoot in children with failed non operative treatment. During the study period, 29 feet of 23 patients with symptomatic flatfoot underwent calcaneal lengthening osteotomy. All patients met the inclusion criteria and were available for clinical and radiological follow-up. The percentage male were (62%)–female were (38%), The mean age at time of surgery was 10.4 years old (7 – 17 years old) and their mean follow up period was 26.2months.The mean functional American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot score had improved from 43.45 (31-55) preoperatively to 85.52 (68-92) postoperatively at last follow up (P value < 0.001) using paired t-test as a significance test for evaluation of pre and post-operative AOFAS score<br /> <strong>Conclusions; </strong>The results of this study support the combination of lateral column lengthening and soft tissue reconstruction for treatment of Plano-valgus foot deformity, The adopted technique revealed satisfactory result both in children and adolescents.
https://bmfj.journals.ekb.eg/article_75839_7a44561e2bf843b3bae0d8d517316244.pdf
Benha University, Faculty of Medicine
Benha Medical Journal
1110-208X
36
3
2020
03
01
The Role of 3D-MSCT Gastric Pouch Volumetric Study In Sleeve Gastrectomy
107
115
75882
10.21608/bmfj.2020.75882
EN
Osama Elsayed
Ahmed
department of radiology, faculty of medicine, banha university
Medhat
Refaat
department of radiology, faculty of medicine, banha university
Ahmed
Shalaan
Department of radiology faculty of medicine, Benha University, Egypt
Journal Article
2020
03
05
<strong>Background: </strong>Laparoscopic sleeve gastrectomy (LSG) has now a surge in popularity in treatment of morbid obesity patients. Multi-slice computed tomography has an increasing role in management of this patients’ group through the availability and efficiency of post processing reconstructive facilities of MSCT software in 3D reconstruction. The purpose of this study is to evaluate MSCT-based volumetric assessment of stomach and gastric sleeves in patients before and after bariatric surgery and correlation between operative gastric volume reduction and body weight reduction.<br /> <strong>Methods: </strong> Thirty sleeve gastrectomy-candidate patients received abdominal MSCT immediately after oral administration of an ionic contrast agent solution. The examination was done pre and three months postoperatively. The gastric and sleeve volumes were measured via 3D volume rendering and 3D masks on dedicated workstations.<br /> <strong>Results: </strong>The correlation between the body weight and gastric volume measured initially in the preoperative state in the studied patients was found to be insignificant. The correlation between body weight reduction percentage and gastric volume reduction percentage in the studied patients was found to be also insignificant.<br /> <strong> </strong><br /> <strong>Conclusion: </strong>MSCT allows crucial anatomical measurements and provides helpful information about the relation between gastric volume reduction and body weight reduction in sleeve gastrectomy-candidate obese patients.
https://bmfj.journals.ekb.eg/article_75882_5701d6a5f14a98a84e75a7b3ec803376.pdf
Benha University, Faculty of Medicine
Benha Medical Journal
1110-208X
36
3
2020
03
01
Advanced MR Imaging Techniques in The Diagnosis of Epilepsy
116
126
75883
10.21608/bmfj.2020.75883
EN
Emad Abdul Azim
Tiba
Department of radiology, Benha faculty of medicine, Benha university, Egypt
Medhat
Refaat
Department of radiology, Benha faculty of medicine, Benha university, Egypt
Medhat
El-sherbiny
Department of radiology, Benha faculty of medicine, Benha university, Egypt
Sameh
Aly
Department of radiology, Benha faculty of medicine, Benha university, Egypt
Journal Article
2020
03
06
<strong>Background</strong>: Once patients have a diagnosis of localization related epilepsy (LRE), it is critical to further classify those patients into lesional or non-lesional for treatment and prognostic reasons. The cornerstone of lesion detection in chronic epilepsy is structural imaging, mainly magnetic resonance imaging. Molecular & Metabolic information from Diffusion weighted MRI & magnetic resonance spectroscopy (MRS) might serve as an additional or as a surrogate marker for the epileptogenic lesion.<br /> <strong>Methods:</strong> 70 patients presented to Aljahra general hospital, Jahra city, Kuwait and were referred to radiology department for MRI study patients represented spectrum for different causes of epilepsy & different age groups All patients was scanned using Semens Aera 1.5 tesla & skyra 3 tesla magnets by conventional MRI ((T1WI, T2WI, FALIR), Diffusion weight images ( DWI/ADC) sequences & MRS were done for patients with SOL, suspected vascular or inflammatory causes. The patients with fits with no MRI signal or structural abnormality are excluded from this study.<br /> <strong>Results</strong>: DWI & MRS can provide additional diagnostic information that may facilitate and support the final diagnosis, especially if clinical symptoms are inconclusive. While conventional imaging provided only anatomical information,<br /> <strong>Conclusion:</strong> Diffusion weighted images (DWI) & SWI with conventional MRI increased accuracy of diagnosis of lesional epilepsy.
https://bmfj.journals.ekb.eg/article_75883_e1d8305a8ce3fbea552517d6361f97bc.pdf
Benha University, Faculty of Medicine
Benha Medical Journal
1110-208X
36
3
2020
03
01
Percutaneous Microwave Ablation of Hepatocellular Carcinoma
127
142
75884
10.21608/bmfj.2020.75884
EN
Ahmed Mohamed
Elsayed
Damanhur national medical institute, radiology department
Medhat
Refaat
department interventional and diagnostic radiology, Faculty of Medicine, Benha University, Egypt
Mohamed
El Shafei
department of interventional and diagnostic radiology, Faculty of medicine, Alexandria University, Egypt
Osama
Galal
department interventional and diagnostic radiology, Faculty of Medicine, Banha University, Egypt
Journal Article
2020
03
06
<strong>Background:</strong> Hepatocellular carcinoma (HCC) is the commonest primary cancer of the liver. Incidence is increasing and HCC has risen to become the 5th commonest malignancy worldwide and the third leading cause of cancer related death. According to the BCLC staging system image-guided tumor ablation is recommended in patients with early stage HCC. Microwave ablation (MWA), is a thermal ablative technique that has recently emerged as a new therapeutic option. The aim of this study was to evaluate the use of microwave ablation in hepatocellular carcinoma treatment and to assess the outcome.<br /> <strong> Methods: </strong>This study was carried out on 52 patients proved to have HCC who presented to Radiology Department in Alexandria University Hospitals. Microwave ablation was performed percutaneously under real-time ultrasound guidance using a GE LOGIQ 5 Pro US scanner (USA) with a 3.5–5 MHz probe, to completely destroy the tumor, as well as the surrounding 0.5–1.0 cm normal appearing liver tissue (safety margins). The patients were observed two hours before discharge. Contrast-enhanced triphasic CT imaging needed to be performed at 1 month after the ablation.<br /> <strong>Results</strong>: All patients completed the procedure safely. The outcome, as determined by dynamic CT performed 1 month after percutaneous MWA, was achieved in 66 (97%) of 68 lesions. The technical success rates for tumors smaller than 3 cm and those 3-5 cm were 97.2% (35 of 36 nodules) and 96.9% (31 of 32 nodules), respectively<br /> <strong> Conclusion:</strong> Thermal ablation, including radiofrequency ablation (RFA) and microwave ablation (MWA), have been shown to be effective for treating HCC. Microwave ablation is a safe, effective and<br /> <br /> <br /> promising technique and a good replacement to surgical interference for patients who are not amenable to surgical therapy.
https://bmfj.journals.ekb.eg/article_75884_8d518540565d6ba48b7a9e679f02a07f.pdf